7XQH
Hemichannel-focused structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction intercellular channel in POPE nanodiscs (GCN-TM1i conformation)
Summary for 7XQH
Entry DOI | 10.2210/pdb7xqh/pdb |
EMDB information | 33396 |
Descriptor | C-terminal deletion mutant of gap junction alpha-1 protein (Cx43-M257) (1 entity in total) |
Functional Keywords | cx43, connexin, gap junction channel, gating mechanism, membrane protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 6 |
Total formula weight | 176379.28 |
Authors | |
Primary citation | Lee, H.J.,Cha, H.J.,Jeong, H.,Lee, S.N.,Lee, C.W.,Kim, M.,Yoo, J.,Woo, J.S. Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM. Nat Commun, 14:931-931, 2023 Cited by PubMed: 36805660DOI: 10.1038/s41467-023-36593-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
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