7XIC

S-ECD (Omicron) in complex with STS165

Summary for 7XIC

• Entry DOI: 10.2210/pdb7xic/pdb
• EMDB information: 33202
• Descriptor: Spike glycoprotein, heavy chain of STS165, light chain of STS165, ... (5 entities in total)
• Functional Keywords: sars-cov-2, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 9
• Total formula weight: 515207.57

Authors

Li, Y.N.,Shen, Y.P.,Zhang, Y.Y.,Yan, R.H. (deposition date: 2022-04-12, release date: 2022-06-15, Last modification date: 2024-11-06)

Primary citation

Li, Y.,Fan, Q.,Zhou, B.,Shen, Y.,Zhang, Y.,Cheng, L.,Qi, F.,Song, S.,Guo, Y.,Yan, R.,Ju, B.,Zhang, Z.
Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants.
Iscience, 25:104431-104431, 2022

PubMed Abstract: The different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have attracted most public concern because they caused "wave and wave" COVID-19 pandemic. The initial step of viral infection is mediated by the SARS-CoV-2 Spike (S) protein, which mediates the receptor recognition and membrane fusion between virus and host cells. Neutralizing antibodies (nAbs) targeting the S protein of SARS-CoV-2 have become promising candidates for clinical intervention strategy, while multiple studies have shown that different variants have enhanced infectivity and antibody resistance. Here, we explore the structure and function of STS165, a broadly inter-Spike bivalent nAb against SARS-CoV-2 variants and even SARS-CoV, contributing to further understanding of the working mechanism of nAbs.

PubMed: 35607524
DOI: 10.1016/j.isci.2022.104431

Experimental method

ELECTRON MICROSCOPY (3.3 Å)