7XIC

S-ECD (Omicron) in complex with STS165

7XIC の概要

• エントリーDOI: 10.2210/pdb7xic/pdb
• EMDBエントリー: 33202
• 分子名称: Spike glycoprotein, heavy chain of STS165, light chain of STS165, ... (5 entities in total)
• 機能のキーワード: sars-cov-2, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 515207.57

構造登録者

Li, Y.N.,Shen, Y.P.,Zhang, Y.Y.,Yan, R.H. (登録日: 2022-04-12, 公開日: 2022-06-15, 最終更新日: 2024-11-06)

主引用文献

Li, Y.,Fan, Q.,Zhou, B.,Shen, Y.,Zhang, Y.,Cheng, L.,Qi, F.,Song, S.,Guo, Y.,Yan, R.,Ju, B.,Zhang, Z.
Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants.
Iscience, 25:104431-104431, 2022

PubMed Abstract: The different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have attracted most public concern because they caused "wave and wave" COVID-19 pandemic. The initial step of viral infection is mediated by the SARS-CoV-2 Spike (S) protein, which mediates the receptor recognition and membrane fusion between virus and host cells. Neutralizing antibodies (nAbs) targeting the S protein of SARS-CoV-2 have become promising candidates for clinical intervention strategy, while multiple studies have shown that different variants have enhanced infectivity and antibody resistance. Here, we explore the structure and function of STS165, a broadly inter-Spike bivalent nAb against SARS-CoV-2 variants and even SARS-CoV, contributing to further understanding of the working mechanism of nAbs.

PubMed: 35607524
DOI: 10.1016/j.isci.2022.104431

実験手法

ELECTRON MICROSCOPY (3.3 Å)