7XHE

Crystal structure of CBP bromodomain liganded with CCS151

7XHE の概要

• エントリーDOI: 10.2210/pdb7xhe/pdb
• 分子名称: CREB-binding protein, (6S)-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(3R)-1-methylsulfonylpyrrolidin-3-yl]benzimidazol-2-yl]-1-(3-fluoranyl-4-methoxy-phenyl)piperidin-2-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: histone acetyltransferase, cbp, bromodomain, protein binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33007.98

構造登録者

Xu, H.,Xiang, Q.,Wang, C.,Zhang, C.,Luo, G.,Wu, X.,Zhang, Y.,Xu, Y. (登録日: 2022-04-08, 公開日: 2022-07-27, 最終更新日: 2023-11-29)

• 主引用文献: Xu, H.,Luo, G.,Wu, T.,Hu, J.,Wang, C.,Wu, X.,Zhang, Y.,Xu, Y.,Xiang, Q.; Structural insights revealed by the cocrystal structure of CCS1477 in complex with CBP bromodomain; Biochem.Biophys.Res.Commun., 623:17-22, 2022; DOI: 10.1016/j.bbrc.2022.07.021

実験手法

X-RAY DIFFRACTION (1.59 Å)