7XH4

Dihydrofolate Reductase-like Protein SacH in safracin biosynthesis complex with safracin A

Summary for 7XH4

• Entry DOI: 10.2210/pdb7xh4/pdb
• Descriptor: Uncharacterized protein sfcH, Safracin A, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: reductase, safracin biosynthesis, self-resistance, complex structure., oxidoreductase
• Biological source: Pseudomonas fluorescens
• Total number of polymer chains: 1
• Total formula weight: 23288.87

Authors

Ma, X.,Shao, N.,Zhang, Y.,Yang, D.,Ma, M.,Tang, G. (deposition date: 2022-04-07, release date: 2023-02-08, Last modification date: 2023-11-29)

• Primary citation: Shao, N.,Ma, X.,Zhang, Y.Y.,Yang, D.,Ma, M.,Tang, G.L.; Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis.; Acta Pharm Sin B, 13:1318-1325, 2023; PubMed: 36970210; DOI: 10.1016/j.apsb.2022.10.005

Experimental method

X-RAY DIFFRACTION (2.2 Å)