7XC3

Crystal structure of SARS-CoV-2 NSP3 Macrodomain 3 (SARS-unique domain-M)

Summary for 7XC3

• Entry DOI: 10.2210/pdb7xc3/pdb
• Descriptor: Papain-like protease nsp3 (2 entities in total)
• Functional Keywords: g-quadruplex-binding macrodomain, sars-unique domain, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 2
• Total formula weight: 28484.72

Authors

Li, J.,Gao, J. (deposition date: 2022-03-22, release date: 2022-11-23, Last modification date: 2023-11-29)

• Primary citation: Li, J.,Zhong, F.,Li, M.,Liu, Y.,Wang, L.,Liu, M.,Li, F.,Zhang, J.,Wu, J.,Shi, Y.,Zhang, Z.,Tu, X.,Ruan, K.,Gao, J.; Two Binding Sites of SARS-CoV-2 Macrodomain 3 Probed by Oxaprozin and Meclomen.; J.Med.Chem., 65:15227-15237, 2022; PubMed: 36356292; DOI: 10.1021/acs.jmedchem.2c01168

Experimental method

X-RAY DIFFRACTION (1.7 Å)