7XAO

Crystal structure of thioredoxin 1

7XAO の概要

• エントリーDOI: 10.2210/pdb7xao/pdb
• 分子名称: Thioredoxin (2 entities in total)
• 機能のキーワード: trx1, thioredoxin1, oxidoreductase
• 由来する生物種: Acinetobacter baumannii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23214.37

構造登録者

Chang, Y.J.,Park, H.H. (登録日: 2022-03-18, 公開日: 2022-06-01, 最終更新日: 2023-11-29)

主引用文献

Chang, Y.J.,Park, H.H.
High-resolution crystal structure of Acinetobacter baumannii thioredoxin 1.
Biochem.Biophys.Res.Commun., 608:1-7, 2022

PubMed Abstract: Thioredoxin (Trx) is a central component of the redox control system that maintains the redox homeostasis critical for organism survival. Owing to its central role in survival, Trx is a prospective target for novel antimicrobial agents. Herein, we report a 1.45 Å high-resolution structure of Trx1 of Acinetobacter baumannii (abTrx1), an antibiotic-resistant pathogenic superbug. Although abTrx1 exhibited the canonical Trx fold, which consists of a four-stranded β-sheet surrounded by four α-helices, structural differences were detected in the loop forming the C-X-X-C redox center and the C-terminal. The unique CAPC sequence of the C-X-X-C motif in the abTrx1 redox center was characterized by mutagenesis. This study contributes to the field of drug designing against superbugs.

PubMed: 35378360
DOI: 10.1016/j.bbrc.2022.03.134

実験手法

X-RAY DIFFRACTION (1.45 Å)