7XAB

Crystal structure of PDE4D catalytic domain complexed with compound 22d

7XAB の概要

• エントリーDOI: 10.2210/pdb7xab/pdb
• 分子名称: Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: pde4 inhibitor, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 117005.73

構造登録者

Huang, Y.-Y.,He, X.,Luo, H.-B. (登録日: 2022-03-17, 公開日: 2023-02-22, 最終更新日: 2023-11-29)

• 主引用文献: Liu, H.,Wang, Q.,Huang, Y.,Deng, J.,Xie, X.,Zhu, J.,Yuan, Y.,He, Y.M.,Huang, Y.Y.,Luo, H.B.,He, X.; Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases.; Eur.J.Med.Chem., 242:114631-114631, 2022; PubMed: 35985255; DOI: 10.1016/j.ejmech.2022.114631

実験手法

X-RAY DIFFRACTION (2.00067450802 Å)