7X9Q

Crystal structure of human STING complexed with compound BSP16

Summary for 7X9Q

• Entry DOI: 10.2210/pdb7x9q/pdb
• Descriptor: Stimulator of interferon genes protein, (2R)-4-(5,6-dimethoxy-1-benzoselenophen-2-yl)-2-ethyl-4-oxidanylidene-butanoic acid (3 entities in total)
• Functional Keywords: sting agonists, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 26389.57

Authors

Pan, L.,Guan, X.,Feng, X.,Li, Z.,Bian, J. (deposition date: 2022-03-15, release date: 2022-09-28, Last modification date: 2023-11-29)

• Primary citation: Feng, X.,Pan, L.,Qian, Z.,Liu, D.,Guan, X.,Feng, L.,Song, B.,Xu, X.,Tan, N.,Ma, Y.,Li, Z.,Wang, Z.,Bian, J.; Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents.; J.Med.Chem., 65:15048-15065, 2022; PubMed: 36069713; DOI: 10.1021/acs.jmedchem.2c00634

Experimental method

X-RAY DIFFRACTION (2.4 Å)