7X8M
NMR Solution Structure of the 2:1 Berberine-KRAS-G4 Complex
Summary for 7X8M
Entry DOI | 10.2210/pdb7x8m/pdb |
Descriptor | DNA (24-MER), BERBERINE (2 entities in total) |
Functional Keywords | g-quadruplex, kras, berberine, dna |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 8212.66 |
Authors | Wang, K.B.,Liu, Y.,Li, J.,Xiao, C.,Gu, W.,Li, Y.,Xia, Y.Z.,Yan, T.,Yang, M.H.,Kong, L.Y. (deposition date: 2022-03-14, release date: 2022-09-07, Last modification date: 2024-05-15) |
Primary citation | Wang, K.B.,Liu, Y.,Li, J.,Xiao, C.,Wang, Y.,Gu, W.,Li, Y.,Xia, Y.Z.,Yan, T.,Yang, M.H.,Kong, L.Y. Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine. Nat Commun, 13:6016-6016, 2022 Cited by PubMed: 36224201DOI: 10.1038/s41467-022-33761-4 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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