7X8G
Crystal structure of ENL T1(H116P) mutant YEATS domain in complex with histone H3 acetylation at K27
Summary for 7X8G
Entry DOI | 10.2210/pdb7x8g/pdb |
Descriptor | Protein ENL, H3K27ac(24-27) peptide (3 entities in total) |
Functional Keywords | yeats domain, complex, histone, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 38638.45 |
Authors | |
Primary citation | Song, L.,Yao, X.,Li, H.,Peng, B.,Boka, A.P.,Liu, Y.,Chen, G.,Liu, Z.,Mathias, K.M.,Xia, L.,Li, Q.,Mir, M.,Li, Y.,Li, H.,Wan, L. Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Mol.Cell, 82:4080-4098.e12, 2022 Cited by PubMed: 36272410DOI: 10.1016/j.molcel.2022.09.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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