7X6K

SARS-CoV-2 3CL protease (3CLpro) in complex with compound 3w

7X6K の概要

• エントリーDOI: 10.2210/pdb7x6k/pdb
• 分子名称: 3C-like proteinase, 1H-indole-2-carbaldehyde (3 entities in total)
• 機能のキーワード: viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33970.71

構造登録者

Su, H.,Nie, T.,Xie, H.,Li, Z.W.,Li, M.J.,Xu, Y. (登録日: 2022-03-07, 公開日: 2022-07-06, 最終更新日: 2023-11-29)

• 主引用文献: Pillaiyar, T.,Flury, P.,Kruger, N.,Su, H.,Schakel, L.,Barbosa Da Silva, E.,Eppler, O.,Kronenberger, T.,Nie, T.,Luedtke, S.,Rocha, C.,Sylvester, K.,Petry, M.R.I.,McKerrow, J.H.,Poso, A.,Pohlmann, S.,Gutschow, M.,O'Donoghue, A.J.,Xu, Y.,Muller, C.E.,Laufer, S.A.; Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination.; J.Med.Chem., 65:9376-9395, 2022; PubMed: 35709506; DOI: 10.1021/acs.jmedchem.2c00636

実験手法

X-RAY DIFFRACTION (2.34 Å)