7WZ9
HSA-In agent complex
Summary for 7WZ9
| Entry DOI | 10.2210/pdb7wz9/pdb |
| Descriptor | Serum albumin, PALMITIC ACID, 16-chloranyl-~{N},~{N}-dimethyl-15-thia-1$l^{4},12$l^{4},13-triaza-16$l^{4}-indatetracyclo[8.6.0.0^{2,7}.0^{12,16}]hexadeca-1,3,5,7,9,11,13-heptaen-14-amine (3 entities in total) |
| Functional Keywords | complex, protein binding |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 68160.99 |
| Authors | Zhang, Z.L.,Yang, F. (deposition date: 2022-02-17, release date: 2023-02-22, Last modification date: 2025-08-20) |
| Primary citation | Zhang, Z.,Yang, T.,Zhang, J.,Li, W.,Li, S.,Sun, H.,Liang, H.,Yang, F. Developing a Novel Indium(III) Agent Based on Human Serum Albumin Nanoparticles: Integrating Bioimaging and Therapy. J.Med.Chem., 65:5392-5406, 2022 Cited by PubMed Abstract: To effectively integrate diagnosis and therapy for tumors, we proposed to develop an indium (In) agent based on the unique property of human serum albumin (HSA) nanoparticles (NPs). A novel In(III) quinoline-2-formaldehyde thiosemicarbazone compound (C5) was optimized with remarkable cytotoxicity and fluorescence to cancer cells . An HSA-C5 complex NP delivery system was then successfully constructed. Importantly, the HSA-C5 complex NPs have stronger bioimaging and therapeutic efficiency relative to C5 alone . Besides, the results of gene chip analysis revealed that C5/HSA-C5 complex NPs act on cancer cells through multiple mechanisms: inducing autophagy, apoptosis, and inhibiting the PI3K-Akt signaling pathway. PubMed: 35324188DOI: 10.1021/acs.jmedchem.1c01790 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.83 Å) |
Structure validation
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