7WWB

Choline transporter-like protein 1

7WWB の概要

• エントリーDOI: 10.2210/pdb7wwb/pdb
• EMDBエントリー: 32865
• 分子名称: Choline transporter-like protein 1, CHOLINE ION, CHOLESTEROL (3 entities in total)
• 機能のキーワード: choline binding, cholesterol binding, transporter, transport protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 147721.34

構造登録者

Chi, X.M.,Zhou, Q. (登録日: 2022-02-12, 公開日: 2022-06-22, 最終更新日: 2025-06-18)

主引用文献

Xie, T.,Chi, X.,Huang, B.,Ye, F.,Zhou, Q.,Huang, J.
Rational exploration of fold atlas for human solute carrier proteins.
Structure, 30:1321-1330.e5, 2022

PubMed Abstract: The solute carrier (SLC) superfamily is the largest group of proteins responsible for the transmembrane transport of substances in human cells. It includes more than 400 members that are organized into 65 families according to their physiological function and sequence similarity. Different families of SLCs can adopt the same or different folds that determine the mechanism and reflect the evolutionary relationship between SLC members. Analysis of structural data in the literature before this work showed 13 different folds in the SLC superfamily covering 40 families and 343 members. To further study their mechanism, we systematically explored the SLC superfamily to look for more folds. Based on our results, at least three new folds are found for the SLC superfamily, one of which is in the choline-like transporter family (SLC44) and has been experimentally verified. Our work has laid a foundation and provided important insights for the systematic and comprehensive study of the structure and function of SLC.

PubMed: 35700727
DOI: 10.1016/j.str.2022.05.015

実験手法

ELECTRON MICROSCOPY (3.86 Å)