7WRX

Structure of Deinococcus radiodurans HerA-ADP complex

7WRX の概要

• エントリーDOI: 10.2210/pdb7wrx/pdb
• 関連するPDBエントリー: 7WRW
• 分子名称: HerA, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE (3 entities in total)
• 機能のキーワード: hexamer, atpase, reca-like, translocase, helicase
• 由来する生物種: Deinococcus radiodurans
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 814604.55

構造登録者

Cheng, K. (登録日: 2022-01-27, 公開日: 2023-02-01, 最終更新日: 2023-11-29)

主引用文献

Yang, J.,Sun, Y.,Wang, Y.,Hao, W.,Cheng, K.
Structural and DNA end resection study of the bacterial NurA-HerA complex.
Bmc Biol., 21:42-42, 2023

PubMed Abstract: The nuclease NurA and the ATPase/translocase HerA play a vital role in repair of double-strand breaks (DSB) during the homologous recombination in archaea. A NurA-HerA complex is known to mediate DSB DNA end resection, leading to formation of a free 3' end used to search for the homologous sequence. Despite the structures of individual archaeal types of NurA and HerA having been reported, there is limited information regarding the molecular mechanisms underlying this process. Some bacteria also possess homologs of NurA and HerA; however, the bacterial type of this complex, as well as the detailed mechanisms underlying the joining of NurA-HerA in DSB DNA end resection, remains unclear.

PubMed: 36829173
DOI: 10.1186/s12915-023-01542-0

実験手法

X-RAY DIFFRACTION (3.40003560509 Å)