7WRP

Crystal Structure of pks13-ACP domain from Corynebacterium diphtheriae

7WRP の概要

• エントリーDOI: 10.2210/pdb7wrp/pdb
• 分子名称: Polyketide synthase involved in mycolic acid biosynthesis, 4'-PHOSPHOPANTETHEINE (3 entities in total)
• 機能のキーワード: acyl-carrier protein, recombination
• 由来する生物種: Corynebacterium diphtheriae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9707.96

構造登録者

Liu, X. (登録日: 2022-01-27, 公開日: 2022-02-23, 最終更新日: 2023-11-29)

主引用文献

Chen, R.,Yuan, J.,Shi, X.,Tang, W.,Liu, X.
Crystal structures of FadD32 and pks13-ACP domain from Corynebacterium diphtheriae.
Biochem.Biophys.Res.Commun., 590:152-157, 2022

PubMed Abstract: Mycolic acids (MAs) are unique components of cell envelope of Mycobacterium or Corynebacterium and are key factors of their virulence to human. In order to develop new anti-Tuberculosis (TB) drugs, many efforts have paid on investigation of structures and functions of proteins involved in the biosynthesis pathway of MAs. FadD32 and polyketide synthase 13 (pks13) catalyze the last step of MAs synthesis. Here we present the crystal structures of FadD32 with substrates and holo-form of ACP-domain from Corynebacterium diphtheriae. The crystal structures and in vitro biochemical assays provide new insights into the assembly of FadD32 and pks13.

PubMed: 34974304
DOI: 10.1016/j.bbrc.2021.12.083

実験手法

X-RAY DIFFRACTION (1.794 Å)