7WR6

Crystal structure of ADP-riboxanated caspase-4 in complex with Af1521

Summary for 7WR6

• Entry DOI: 10.2210/pdb7wr6/pdb
• Descriptor: Caspase-4, ADP-ribose glycohydrolase AF_1521, [[(3~{a}~{S},5~{R},6~{R},6~{a}~{R})-2-azanylidene-3-[(4~{R})-4-azanyl-5-oxidanylidene-pentyl]-6-oxidanyl-3~{a},5,6,6~{a}-tetrahydrofuro[2,3-d][1,3]oxazol-5-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate, ... (4 entities in total)
• Functional Keywords: adp-riboxanation, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 54483.95

Authors

Hou, Y.J.,Zeng, H.,Shao, F.,Ding, J. (deposition date: 2022-01-26, release date: 2023-01-25, Last modification date: 2023-11-29)

• Primary citation: Hou, Y.,Zeng, H.,Li, Z.,Feng, N.,Meng, F.,Xu, Y.,Li, L.,Shao, F.,Ding, J.; Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis.; Nat.Struct.Mol.Biol., 30:261-272, 2023; PubMed: 36624349; DOI: 10.1038/s41594-022-00888-3

Experimental method

X-RAY DIFFRACTION (1.96 Å)