7WQH

Crystal structure of HCoV-NL63 main protease with PF07304814

7WQH の概要

• エントリーDOI: 10.2210/pdb7wqh/pdb
• 分子名称: 3C-like proteinase, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate (3 entities in total)
• 機能のキーワード: viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Human coronavirus NL63
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65746.35

構造登録者

Zhong, F.L.,Zhou, X.L.,Lin, C.,Zeng, P.,Li, J.,Zhang, J. (登録日: 2022-01-25, 公開日: 2022-08-24, 最終更新日: 2023-11-29)

• 主引用文献: Li, J.,Lin, C.,Zhou, X.,Zhong, F.,Zeng, P.,McCormick, P.J.,Jiang, H.,Zhang, J.; Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814; J.Mol.Biol., 434:167706-, 2022; DOI: 10.1016/j.jmb.2022.167706

実験手法

X-RAY DIFFRACTION (2.32 Å)