7WMN

A novel chemical derivative(89) of THRB agonist

7WMN の概要

• エントリーDOI: 10.2210/pdb7wmn/pdb
• 分子名称: Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2, 2-[[7-[2,6-dimethyl-4-(3-methylphenyl)carbonyl-phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, ... (4 entities in total)
• 機能のキーワード: transcription factor, ligand, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31275.10

構造登録者

Yao, B.Q.,Li, Y. (登録日: 2022-01-15, 公開日: 2022-05-18, 最終更新日: 2023-11-29)

• 主引用文献: Li, Q.,Yao, B.,Zhao, S.,Lu, Z.,Zhang, Y.,Xiang, Q.,Wu, X.,Yu, H.,Zhang, C.,Li, J.,Zhuang, X.,Wu, D.,Li, Y.,Xu, Y.; Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.; J.Med.Chem., 65:7193-7211, 2022; PubMed: 35507418; DOI: 10.1021/acs.jmedchem.2c00144

実験手法

X-RAY DIFFRACTION (2.57 Å)