7WJ7

Crystal Structure of the Kinase Domain with Adenosine of a Class III Lanthipeptide Synthetase CurKC

Summary for 7WJ7

• Entry DOI: 10.2210/pdb7wj7/pdb
• Descriptor: Serine/threonine protein kinase, 2-(6-AMINO-OCTAHYDRO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL (3 entities in total)
• Functional Keywords: lanthipeptide synthetase, class iii, curkc, curvopeptin, biosynthetic protein
• Biological source: Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9)
• Total number of polymer chains: 2
• Total formula weight: 60891.09

Authors

Huang, S.,Wang, H. (deposition date: 2022-01-05, release date: 2022-11-09, Last modification date: 2023-11-29)

• Primary citation: Huang, S.,Wang, Y.,Cai, C.,Xiao, X.,Liu, S.,Ma, Y.,Xie, X.,Liang, Y.,Chen, H.,Zhu, J.,Hegemann, J.D.,Yao, H.,Wei, W.,Wang, H.; Discovery of a Unique Structural Motif in Lanthipeptide Synthetases for Substrate Binding and Interdomain Interactions.; Angew.Chem.Int.Ed.Engl., 61:e202211382-e202211382, 2022; PubMed: 36102578; DOI: 10.1002/anie.202211382

Experimental method

X-RAY DIFFRACTION (2.55 Å)