7W06

Itaconate inducible LysR-Type Transcriptional regulator (ITCR) in complex with itaconate (SeMet labeled), Space group C121.

Summary for 7W06

Entry DOI	10.2210/pdb7w06/pdb
Descriptor	Transcriptional regulator, LysR family, 2-methylidenebutanedioic acid, SULFATE ION, ... (5 entities in total)
Functional Keywords	lttr, itcr, itaconate, transcription
Biological source	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
Total number of polymer chains	1
Total formula weight	32894.81
Authors	Sun, P.K.,Wang, B.,Wang, Z.X.,Qi, S.,Li, X.J. (deposition date: 2021-11-17, release date: 2022-10-26, Last modification date: 2022-11-16)
Primary citation	Sun, P.,Zhang, Z.,Wang, B.,Liu, C.,Chen, C.,Liu, P.,Li, X. A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nat Commun, 13:6562-6562, 2022 Cited by PubMed: 36333306 DOI: 10.1038/s41467-022-34306-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation