7VZZ

The structure of GdmN in complex with the natural tetrahedral intermediate, carbamoyl adenylate, and 20-O-methyl-19-chloroproansamitocin

Summary for 7VZZ

• Entry DOI: 10.2210/pdb7vzz/pdb
• Descriptor: GdmN, 1,2-ETHANEDIOL, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl [(~{S})-azanyl-[[(5~{S},6~{E},8~{S},9~{S},12~{R},13~{E},15~{E})-21-chloranyl-12,20-dimethoxy-6,8,16-trimethyl-5-oxidanyl-3,11-bis(oxidanylidene)-2-azabicyclo[16.3.1]docosa-1(21),6,13,15,18(22),19-hexaen-9-yl]oxy]-oxidanyl-methyl] hydrogen phosphate, ... (8 entities in total)
• Functional Keywords: homodimer, carbamoyltransferase, ansamycins antibiotics, transferase
• Biological source: Streptomyces hygroscopicus
• Total number of polymer chains: 2
• Total formula weight: 156429.48

Authors

Wei, J.,Zheng, J.,Zhou, J.,Kang, Q.,Bai, L. (deposition date: 2021-11-17, release date: 2022-11-16, Last modification date: 2023-11-29)

• Primary citation: Wei, J.,Zhang, X.,Zhou, Y.,Cheng, X.,Lin, Z.,Tang, M.,Zheng, J.,Wang, B.,Kang, Q.,Bai, L.; Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies.; Nat Commun, 13:6617-6617, 2022; PubMed: 36329057; DOI: 10.1038/s41467-022-34387-2

Experimental method

X-RAY DIFFRACTION (2.85 Å)