7VZN

The structure of GdmN in complex with carbamoyl adenylate intermediate and 20-O-methyl-19-chloroproansamitocin

7VZN の概要

• エントリーDOI: 10.2210/pdb7vzn/pdb
• 分子名称: GdmN, FE (III) ION, (5~{S},6~{E},8~{S},9~{S},12~{R},15~{E})-21-chloranyl-12,20-dimethoxy-6,8,16-trimethyl-5,9-bis(oxidanyl)-2-azabicyclo[16.3.1]docosa-1(21),6,15,18(22),19-pentaene-3,11-dione, ... (10 entities in total)
• 機能のキーワード: homodimer, carbamoyltransferase, ansamycins antibiotics, transferase
• 由来する生物種: Streptomyces hygroscopicus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 152071.74

構造登録者

Wei, J.,Zheng, J.,Zhou, J.,Kang, Q.,Bai, L. (登録日: 2021-11-16, 公開日: 2022-11-16, 最終更新日: 2023-11-29)

• 主引用文献: Wei, J.,Zhang, X.,Zhou, Y.,Cheng, X.,Lin, Z.,Tang, M.,Zheng, J.,Wang, B.,Kang, Q.,Bai, L.; Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies.; Nat Commun, 13:6617-6617, 2022; PubMed: 36329057; DOI: 10.1038/s41467-022-34387-2

実験手法

X-RAY DIFFRACTION (2.1 Å)