7VUN

Design, modification, evaluation and cocrystal studies of novel phthalimides regulating PD-1/PD-L1 interaction

7VUN の概要

• エントリーDOI: 10.2210/pdb7vun/pdb
• 分子名称: Programmed cell death 1 ligand 1, (2~{S},3~{S})-2-[[6-[(3-cyanophenyl)methoxy]-2-(2-methyl-3-phenyl-phenyl)-1,3-bis(oxidanylidene)isoindol-5-yl]methylamino]-3-oxidanyl-butanoic acid (3 entities in total)
• 機能のキーワード: dimer, beta-sheet, structural protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 117522.16

構造登録者

Cheng, Y.,Sun, C.L.,Chen, M.R.,Yang, P.,Xiao, Y.B. (登録日: 2021-11-03, 公開日: 2022-09-14, 最終更新日: 2023-11-29)

• 主引用文献: Sun, C.,Cheng, Y.,Liu, X.,Wang, G.,Min, W.,Wang, X.,Yuan, K.,Hou, Y.,Li, J.,Zhang, H.,Dong, H.,Wang, L.,Lou, C.,Sun, Y.,Yu, X.,Deng, H.,Xiao, Y.,Yang, P.; Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents.; Acta Pharm Sin B, 12:4446-4457, 2022; PubMed: 36561991; DOI: 10.1016/j.apsb.2022.04.007

実験手法

X-RAY DIFFRACTION (2.701 Å)