7VS2

secreted fungal effector protein MoErs1

7VS2 の概要

• エントリーDOI: 10.2210/pdb7vs2/pdb
• 分子名称: MoErs1 (2 entities in total)
• 機能のキーワード: effector, host immunity, magnaporthe oryzae, rice blast control, immune system
• 由来する生物種: Magnaporthe oryzae (Rice blast fungus, Pyricularia oryzae)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20856.31

構造登録者

Wang, F.F.,Xing, W.M. (登録日: 2021-10-25, 公開日: 2023-08-02, 最終更新日: 2024-10-09)

主引用文献

Liu, M.,Wang, F.,He, B.,Hu, J.,Dai, Y.,Chen, W.,Yi, M.,Zhang, H.,Ye, Y.,Cui, Z.,Zheng, X.,Wang, P.,Xing, W.,Zhang, Z.
Targeting Magnaporthe oryzae effector MoErs1 and host papain-like protease OsRD21 interaction to combat rice blast.
Nat.Plants, 2024

PubMed Abstract: Effector proteins secreted by plant pathogenic fungi are important artilleries against host immunity, but there is no precedent of such effectors being explored as antifungal targets. Here we demonstrate that MoErs1, a species-specific effector protein secreted by the rice blast fungus Magnaporthe oryzae, inhibits the function of rice papain-like cysteine protease OsRD21 involved in rice immunity. Disrupting MoErs1-OsRD21 interaction effectively controls rice blast. In addition, we show that FY21001, a structure-function-based designer compound, specifically binds to and inhibits MoErs1 function. FY21001 significantly and effectively controls rice blast in field tests. Our study revealed a novel concept of targeting pathogen-specific effector proteins to prevent and manage crop diseases.

PubMed: 38409290
DOI: 10.1038/s41477-024-01642-x

実験手法

X-RAY DIFFRACTION (2.5 Å)