7VQS

Crystal structure of LSD1 in complex with compound 4

7VQS の概要

• エントリーDOI: 10.2210/pdb7vqs/pdb
• 分子名称: Lysine-specific histone demethylase 1A, GLYCEROL, L(+)-TARTARIC ACID, ... (5 entities in total)
• 機能のキーワード: demethylase, amine oxidase, chromatin, histone, fad, mechanism-based inhibitor, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 75932.31

構造登録者

Niwa, H.,Koda, Y.,Sato, S.,Yamamoto, H.,Koyama, H.,Umehara, T. (登録日: 2021-10-20, 公開日: 2022-06-01, 最終更新日: 2023-11-29)

• 主引用文献: Koda, Y.,Sato, S.,Yamamoto, H.,Niwa, H.,Watanabe, H.,Watanabe, C.,Sato, T.,Nakamura, K.,Tanaka, A.,Shirouzu, M.,Honma, T.,Fukami, T.,Koyama, H.,Umehara, T.; Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles.; Acs Med.Chem.Lett., 13:848-854, 2022; PubMed: 35586426; DOI: 10.1021/acsmedchemlett.2c00120

実験手法

X-RAY DIFFRACTION (2.94 Å)