7VPR

Crystal structure of the ligand-binding domain of C. glabrata Upc2 in complex with ergosterol

Summary for 7VPR

• Entry DOI: 10.2210/pdb7vpr/pdb
• Descriptor: Sterol uptake control protein 2 (Upc2), ERGOSTEROL (3 entities in total)
• Functional Keywords: ergosterol, transcription factor, ligand-binding, zinc finger, transcription
• Biological source: [Candida] glabrata CBS 138 (Yeast, Torulopsis glabrata)
• Total number of polymer chains: 4
• Total formula weight: 138555.47

Authors

Tan, L.,Im, Y.J. (deposition date: 2021-10-17, release date: 2022-09-07, Last modification date: 2023-11-29)

• Primary citation: Tan, L.,Chen, L.,Yang, H.,Jin, B.,Kim, G.,Im, Y.J.; Structural basis for activation of fungal sterol receptor Upc2 and azole resistance.; Nat.Chem.Biol., 18:1253-1262, 2022; PubMed: 36229681; DOI: 10.1038/s41589-022-01117-0

Experimental method

X-RAY DIFFRACTION (2.59 Å)