7VP9

Crystal structure of human ClpP in complex with ZG111

Summary for 7VP9

• Entry DOI: 10.2210/pdb7vp9/pdb
• Descriptor: ATP-dependent Clp protease proteolytic subunit, mitochondrial, (6S,9aS)-N-[(4-bromophenyl)methyl]-6-[(2S)-butan-2-yl]-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: mitochondrial protease, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 14
• Total formula weight: 347084.21

Authors

Wang, P.Y.,Gan, J.H.,Yang, C.-G. (deposition date: 2021-10-15, release date: 2022-06-08, Last modification date: 2023-11-29)

• Primary citation: Wang, P.,Zhang, T.,Wang, X.,Xiao, H.,Li, H.,Zhou, L.L.,Yang, T.,Wei, B.,Zhu, Z.,Zhou, L.,Yang, S.,Lu, X.,Zhang, Y.,Huang, Y.,Gan, J.,Yang, C.G.; Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma.; Cell Chem Biol, 29:1396-1408.e8, 2022; PubMed: 35905743; DOI: 10.1016/j.chembiol.2022.07.002

Experimental method

X-RAY DIFFRACTION (2.552 Å)