7VLP

Crystal structure of SARS-Cov-2 main protease in complex with PF07321332 in spacegroup P1211

7VLP の概要

• エントリーDOI: 10.2210/pdb7vlp/pdb
• 分子名称: Replicase polyprotein 1a, (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide (3 entities in total)
• 機能のキーワード: viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68480.02

構造登録者

Zhou, X.L.,Zhong, F.L.,Lin, C.,Li, J.,Zhang, J. (登録日: 2021-10-05, 公開日: 2022-04-06, 最終更新日: 2023-11-29)

• 主引用文献: Li, J.,Lin, C.,Zhou, X.,Zhong, F.,Zeng, P.,Yang, Y.,Zhang, Y.,Yu, B.,Fan, X.,McCormick, P.J.,Fu, R.,Fu, Y.,Jiang, H.,Zhang, J.; Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332.; J.Virol., 96:e0201321-e0201321, 2022; PubMed: 35389231; DOI: 10.1128/jvi.02013-21

実験手法

X-RAY DIFFRACTION (1.50251932385 Å)