7VJL

The crystal structure of FGFR4 kinase domain in complex with N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-(2,2,2-trifluoroacetyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

7VJL の概要

• エントリーDOI: 10.2210/pdb7vjl/pdb
• 分子名称: Fibroblast growth factor receptor 4, N-[5-(aminomethyl)-4-(2-methoxyethylamino)pyridin-2-yl]-7-[2,2,2-tris(fluoranyl)ethanoyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide (2 entities in total)
• 機能のキーワード: fgfr4, transferase inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68508.87

構造登録者

Zhang, Z.M.,Wang, Y.J. (登録日: 2021-09-28, 公開日: 2022-02-23, 最終更新日: 2023-11-29)

• 主引用文献: Zhang, Z.,Wang, Y.,Chen, X.,Song, X.,Tu, Z.,Chen, Y.,Zhang, Z.,Ding, K.; Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design.; Bioorg.Med.Chem., 50:116457-116457, 2021; PubMed: 34670167; DOI: 10.1016/j.bmc.2021.116457

実験手法

X-RAY DIFFRACTION (2.90017299719 Å)