7V1U

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZJ12

Summary for 7V1U

• Entry DOI: 10.2210/pdb7v1u/pdb
• Descriptor: Bromodomain-containing protein 4, ~{N}-(3-ethyl-6-methoxy-1,2-benzoxazol-5-yl)-2-methoxy-benzenesulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: brd4(1), bromodomain, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 17191.79

Authors

Zhang, M.,Wang, C.,Zhang, C.,Zhang, Y.,Xu, Y. (deposition date: 2021-08-06, release date: 2022-08-10, Last modification date: 2023-11-29)

• Primary citation: Zhang, M.F.,Luo, X.Y.,Zhang, C.,Wang, C.,Wu, X.S.,Xiang, Q.P.,Xu, Y.,Zhang, Y.; Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.; Acta Pharmacol.Sin., 43:2735-2748, 2022; PubMed: 35264812; DOI: 10.1038/s41401-022-00881-y

Experimental method

X-RAY DIFFRACTION (1.82 Å)