7V1U

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZJ12

7V1U の概要

• エントリーDOI: 10.2210/pdb7v1u/pdb
• 分子名称: Bromodomain-containing protein 4, ~{N}-(3-ethyl-6-methoxy-1,2-benzoxazol-5-yl)-2-methoxy-benzenesulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: brd4(1), bromodomain, protein binding
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17191.79

構造登録者

Zhang, M.,Wang, C.,Zhang, C.,Zhang, Y.,Xu, Y. (登録日: 2021-08-06, 公開日: 2022-08-10, 最終更新日: 2023-11-29)

• 主引用文献: Zhang, M.F.,Luo, X.Y.,Zhang, C.,Wang, C.,Wu, X.S.,Xiang, Q.P.,Xu, Y.,Zhang, Y.; Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.; Acta Pharmacol.Sin., 43:2735-2748, 2022; PubMed: 35264812; DOI: 10.1038/s41401-022-00881-y

実験手法

X-RAY DIFFRACTION (1.82 Å)