7V0W

Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2,5 )pA

Summary for 7V0W

• Entry DOI: 10.2210/pdb7v0w/pdb
• Descriptor: Cyclic GMP-AMP synthase, Palindromic DNA18, ZINC ION, ... (7 entities in total)
• Functional Keywords: 5 -pppg(2, 5 )pa, transferase-dna complex, transferase/dna
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 6
• Total formula weight: 109316.47

Authors

Wu, S.,Gabelli, S.B.,Sohn, J. (deposition date: 2022-05-11, release date: 2023-05-17, Last modification date: 2024-05-29)

• Primary citation: Wu, S.,Gabelli, S.B.,Sohn, J.; The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS; Nat Commun, 15:4012-, 2024; DOI: 10.1038/s41467-024-48365-3

Experimental method

X-RAY DIFFRACTION (2.66 Å)