7V0R
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -ppcpG(2 ,5 )pA
Summary for 7V0R
Entry DOI | 10.2210/pdb7v0r/pdb |
Descriptor | Cyclic GMP-AMP synthase, Palindromic DNA18, [(2~{R},3~{R},4~{R},5~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-[[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid, ... (6 entities in total) |
Functional Keywords | complex, ppcpgpa, magnesium, immune system, transferase-dna complex, transferase/dna |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 109267.79 |
Authors | Wu, S.,Gabelli, S.B.,Sohn, J. (deposition date: 2022-05-10, release date: 2023-05-10, Last modification date: 2023-10-25) |
Primary citation | Wu, S.,Gabelli, S.B.,Sohn, J.S. Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -ppcpG(2 ,5 )pA To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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