7V0O

Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a moderately/weakly neutralizing human antibody IgG-94

7V0O の概要

• エントリーDOI: 10.2210/pdb7v0o/pdb
• EMDBエントリー: 26946
• 分子名称: Spike glycoprotein E1, IgG 94 Fab heavy chain, IgG 94 Fab light chain, ... (4 entities in total)
• 機能のキーワード: cryo-em, single particle, virus neutralization, inter-virion crosslink, aggregation, virus-immune system complex, virus/immune system
• 由来する生物種: Eastern equine encephalitis virus; 詳細
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 475351.41

構造登録者

Bandyopadhyay, A.,Klose, T.,Kuhn, R.J. (登録日: 2022-05-10, 公開日: 2023-04-05, 最終更新日: 2024-02-21)

• 主引用文献: Williamson, L.E.,Bandyopadhyay, A.,Bailey, K.,Sirohi, D.,Klose, T.,Julander, J.G.,Kuhn, R.J.,Crowe Jr., J.E.; Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies.; Proc.Natl.Acad.Sci.USA, 120:e2213690120-e2213690120, 2023; PubMed: 36961925; DOI: 10.1073/pnas.2213690120

実験手法

ELECTRON MICROSCOPY (6.6 Å)