7UZ2

Structure of beta-glycosidase from Sulfolobus solfataricus in complex with C5a-fluoro-valienide.

7UZ2 の概要

• エントリーDOI: 10.2210/pdb7uz2/pdb
• 分子名称: Beta-galactosidase, (1R,2S,3R,4R)-5-fluoro-6-(hydroxymethyl)cyclohex-5-ene-1,2,3,4-tetrol (3 entities in total)
• 機能のキーワード: covalent inhibition, glycoside hydrolase, hydrolase
• 由来する生物種: Saccharolobus solfataricus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114041.25

構造登録者

Danby, P.M.,Jeong, A.,Sim, L.,Sweeney, R.P.,Wardman, J.F.,Geissner, A.,Worrall, L.J.,Strynadka, N.C.J.,Withers, S.G. (登録日: 2022-05-08, 公開日: 2023-04-05, 最終更新日: 2023-10-25)

• 主引用文献: Danby, P.M.,Jeong, A.,Sim, L.,Sweeney, R.P.,Wardman, J.F.,Karimi, R.,Geissner, A.,Worrall, L.J.,Reid, J.P.,Strynadka, N.C.J.,Withers, S.G.; Vinyl Halide-Modified Unsaturated Cyclitols are Mechanism-Based Glycosidase Inhibitors.; Angew.Chem.Int.Ed.Engl., 62:e202301258-e202301258, 2023; PubMed: 36940280; DOI: 10.1002/anie.202301258

実験手法

X-RAY DIFFRACTION (1.83 Å)