7USK

BRD4-BD2 Ligand free

Summary for 7USK

Entry DOI	10.2210/pdb7usk/pdb
Descriptor	Bromodomain-containing protein 4, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	acetyllysine binding pocket, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	13140.41
Authors	Jayasinghe, T.D.,Ronning, D.R. (deposition date: 2022-04-25, release date: 2023-01-18, Last modification date: 2023-10-25)
Primary citation	Sethi, B.,Kumar, V.,Jayasinghe, T.D.,Dong, Y.,Ronning, D.R.,Zhong, H.A.,Coulter, D.W.,Mahato, R.I. Targeting BRD4 and PI3K signaling pathways for the treatment of medulloblastoma. J Control Release, 354:80-90, 2023 Cited by PubMed: 36599397 DOI: 10.1016/j.jconrel.2022.12.055 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.22 Å)

Structure validation