7UP5
Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound pyrrolopyrimidine compound 23 (co-crystal)
Summary for 7UP5
Entry DOI | 10.2210/pdb7up5/pdb |
Descriptor | Ribosomal protein S6 kinase alpha-5, (2M)-6-chloro-2-(5H-pyrrolo[3,2-d]pyrimidin-5-yl)pyridine-3-carbonitrile, IODIDE ION, ... (4 entities in total) |
Functional Keywords | msk1, c-terminal domain, protein kinase, transferase, phosphorylation |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 70229.66 |
Authors | Yano, J.K.,Edwards, T.E.,Hall, A. (deposition date: 2022-04-14, release date: 2022-07-06, Last modification date: 2024-04-03) |
Primary citation | Hall, A.,Abendroth, J.,Bolejack, M.J.,Ceska, T.,Dell'Aiera, S.,Ellis, V.,Fox 3rd, D.,Francois, C.,Muruthi, M.M.,Prevel, C.,Poullennec, K.,Romanov, S.,Valade, A.,Vanbellinghen, A.,Yano, J.,Geraerts, M. Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1. Acs Med.Chem.Lett., 13:1099-1108, 2022 Cited by PubMed: 35859861DOI: 10.1021/acsmedchemlett.2c00134 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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