7UKR
Crystal Structure of SOS1 with MRTX0902, a Potent and Selective Inhibitor of the SOS1:KRAS Protein-Protein Interaction
Summary for 7UKR
Entry DOI | 10.2210/pdb7ukr/pdb |
Descriptor | Son of sevenless homolog 1, 2-methyl-3-[(1R)-1-{[4-methyl-7-(morpholin-4-yl)pyrido[3,4-d]pyridazin-1-yl]amino}ethyl]benzonitrile (3 entities in total) |
Functional Keywords | sos1, kras, ras, protein-protein interaction, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 114983.50 |
Authors | Gunn, R.J.,Lawson, J.D.,Ketcham, J.M.,Marx, M.A. (deposition date: 2022-04-01, release date: 2022-07-27, Last modification date: 2023-10-18) |
Primary citation | Ketcham, J.M.,Haling, J.,Khare, S.,Bowcut, V.,Briere, D.M.,Burns, A.C.,Gunn, R.J.,Ivetac, A.,Kuehler, J.,Kulyk, S.,Laguer, J.,Lawson, J.D.,Moya, K.,Nguyen, N.,Rahbaek, L.,Saechao, B.,Smith, C.R.,Sudhakar, N.,Thomas, N.C.,Vegar, L.,Vanderpool, D.,Wang, X.,Yan, L.,Olson, P.,Christensen, J.G.,Marx, M.A. Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction. J.Med.Chem., 65:9678-9690, 2022 Cited by PubMed: 35833726DOI: 10.1021/acs.jmedchem.2c00741 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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