7UKK
Room-temperature X-ray structure of SARS-CoV-2 main protease in complex with GC-376
Summary for 7UKK
Entry DOI | 10.2210/pdb7ukk/pdb |
Related PRD ID | PRD_002495 |
Descriptor | 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total) |
Functional Keywords | cysteine protease, catalytic domain, viral enzyme, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 1 |
Total formula weight | 34311.10 |
Authors | Kovalevsky, A.,Kneller, D.W.,Coates, L. (deposition date: 2022-04-01, release date: 2022-10-05, Last modification date: 2023-10-18) |
Primary citation | Nashed, N.T.,Kneller, D.W.,Coates, L.,Ghirlando, R.,Aniana, A.,Kovalevsky, A.,Louis, J.M. Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain. Commun Biol, 5:976-976, 2022 Cited by PubMed: 36114420DOI: 10.1038/s42003-022-03910-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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