7UKK

Room-temperature X-ray structure of SARS-CoV-2 main protease in complex with GC-376

7UKK の概要

• エントリーDOI: 10.2210/pdb7ukk/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002495
• 分子名称: 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total)
• 機能のキーワード: cysteine protease, catalytic domain, viral enzyme, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34311.10

構造登録者

Kovalevsky, A.,Kneller, D.W.,Coates, L. (登録日: 2022-04-01, 公開日: 2022-10-05, 最終更新日: 2023-10-18)

• 主引用文献: Nashed, N.T.,Kneller, D.W.,Coates, L.,Ghirlando, R.,Aniana, A.,Kovalevsky, A.,Louis, J.M.; Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain.; Commun Biol, 5:976-976, 2022; PubMed: 36114420; DOI: 10.1038/s42003-022-03910-y

実験手法

X-RAY DIFFRACTION (2 Å)