7UK2

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with NN-390

7UK2 の概要

• エントリーDOI: 10.2210/pdb7uk2/pdb
• 分子名称: Hdac6 protein, N-hydroxy-4-{[(propan-2-yl)(2,3,4,5-tetrafluorobenzene-1-sulfonyl)amino]methyl}benzamide, ZINC ION, ... (5 entities in total)
• 機能のキーワード: potassium ion binding, alkali metal ion binding, ion binding, cation binding, metal ion binding, catalytic activity, hydrolase activity, deacetylase activity, protein deacetylase activity, acting on a protein, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, tubulin deacetylase activity, zinc ion binding, transition metal ion binding, metal binding protein, metal binding protein-inhibitor complex, metal binding protein/inhibitor
• 由来する生物種: Danio rerio (zebrafish)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40288.96

構造登録者

Erdogan, F.,Seo, H.-S.,Dhe-Paganon, S. (登録日: 2022-03-31, 公開日: 2022-11-02, 最終更新日: 2023-10-25)

• 主引用文献: Garcha, H.K.,Nawar, N.,Sorger, H.,Erdogan, F.,Aung, M.M.K.,Sedighi, A.,Manaswiyoungkul, P.,Seo, H.S.,Schonefeldt, S.,Poloske, D.,Dhe-Paganon, S.,Neubauer, H.A.,Mustjoki, S.M.,Herling, M.,de Araujo, E.D.,Moriggl, R.,Gunning, P.T.; High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma.; Pharmaceuticals, 15:-, 2022; PubMed: 36355493; DOI: 10.3390/ph15111321

実験手法

X-RAY DIFFRACTION (1.6 Å)