7UHC
SARS-CoV-2 spike in complex with AHB2-2GS-SB175
7UHC の概要
エントリーDOI | 10.2210/pdb7uhc/pdb |
EMDBエントリー | 26512 |
分子名称 | Spike glycoprotein, Multivalent miniprotein inhibitor AHB2-2GS-SB175, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
機能のキーワード | sars-cov-2, covid-19, spike glycoprotein, fusion protein, miniprotein inhibitor, structural genomics, seattle structural genomics center for infectious disease, ssgcid, viral protein |
由来する生物種 | Severe acute respiratory syndrome coronavirus 2 詳細 |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 493035.98 |
構造登録者 | Park, Y.J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID),Veesler, D. (登録日: 2022-03-26, 公開日: 2022-06-08, 最終更新日: 2024-05-08) |
主引用文献 | Hunt, A.C.,Case, J.B.,Park, Y.J.,Cao, L.,Wu, K.,Walls, A.C.,Liu, Z.,Bowen, J.E.,Yeh, H.W.,Saini, S.,Helms, L.,Zhao, Y.T.,Hsiang, T.Y.,Starr, T.N.,Goreshnik, I.,Kozodoy, L.,Carter, L.,Ravichandran, R.,Green, L.B.,Matochko, W.L.,Thomson, C.A.,Vogeli, B.,Kruger, A.,VanBlargan, L.A.,Chen, R.E.,Ying, B.,Bailey, A.L.,Kafai, N.M.,Boyken, S.E.,Ljubetic, A.,Edman, N.,Ueda, G.,Chow, C.M.,Johnson, M.,Addetia, A.,Navarro, M.J.,Panpradist, N.,Gale Jr., M.,Freedman, B.S.,Bloom, J.D.,Ruohola-Baker, H.,Whelan, S.P.J.,Stewart, L.,Diamond, M.S.,Veesler, D.,Jewett, M.C.,Baker, D. Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice. Sci Transl Med, 14:eabn1252-eabn1252, 2022 Cited by PubMed: 35412328DOI: 10.1126/scitranslmed.abn1252 主引用文献が同じPDBエントリー |
実験手法 | ELECTRON MICROSCOPY (3.1 Å) |
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