7UGP

Cryo-EM structure of BG24 Fabs with an inferred germline light chain and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 containing the N276 gp120 glycan- Class 1

7UGP の概要

• エントリーDOI: 10.2210/pdb7ugp/pdb
• EMDBエントリー: 26493
• 分子名称: Envelope glycoprotein gp120, 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp41, ... (10 entities in total)
• 機能のキーワード: hiv-1 env, neutralizing antibody, cd4 binding site antibody, viral protein, germline, precursor, immunogen, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 18
• 化学式量合計: 359748.76

構造登録者

Dam, K.A.,Bjorkman, P.J. (登録日: 2022-03-25, 公開日: 2022-11-09, 最終更新日: 2022-11-16)

• 主引用文献: Dam, K.A.,Barnes, C.O.,Gristick, H.B.,Schoofs, T.,Gnanapragasam, P.N.P.,Nussenzweig, M.C.,Bjorkman, P.J.; HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design.; Nat Commun, 13:6123-6123, 2022; PubMed: 36253376; DOI: 10.1038/s41467-022-33860-2

実験手法

ELECTRON MICROSCOPY (4.2 Å)