7UGO

Cryo-EM structure of BG24 inferred germline Fabs with mature CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1

7UGO の概要

• エントリーDOI: 10.2210/pdb7ugo/pdb
• EMDBエントリー: 26492
• 分子名称: Envelope glycoprotein gp120, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (15 entities in total)
• 機能のキーワード: hiv-1 env, neutralizing antibody, cd4 binding site antibody, viral protein, germline, precursor, immunogen, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 18
• 化学式量合計: 372364.32

構造登録者

Dam, K.A.,Bjorkman, P.J. (登録日: 2022-03-25, 公開日: 2022-10-26)

• 主引用文献: Dam, K.A.,Barnes, C.O.,Gristick, H.B.,Schoofs, T.,Gnanapragasam, P.N.P.,Nussenzweig, M.C.,Bjorkman, P.J.; HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design.; Nat Commun, 13:6123-6123, 2022; PubMed: 36253376; DOI: 10.1038/s41467-022-33860-2

実験手法

ELECTRON MICROSCOPY (4.1 Å)