7UGL

Bromodomain of CBP liganded with BMS-536924 and SGC-CBP30

Summary for 7UGL

• Entry DOI: 10.2210/pdb7ugl/pdb
• Descriptor: Histone acetyltransferase, (3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, ... (4 entities in total)
• Functional Keywords: bromodomain, small molecule ligand, complex, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 29673.76

Authors

Schonbrunn, E.,Bikowitz, M. (deposition date: 2022-03-24, release date: 2023-04-12, Last modification date: 2023-10-25)

• Primary citation: Schonbrunn, E.,Bikowitz, M.; Structural basis of CBP and EP300 interaction with kinase inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.5 Å)