7UFE
Human CYP3A4 bound to an inhibitor
Summary for 7UFE
Entry DOI | 10.2210/pdb7ufe/pdb |
Descriptor | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ... (5 entities in total) |
Functional Keywords | cyp3a4, inhibitor, complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 113869.88 |
Authors | Sevrioukova, I.F. (deposition date: 2022-03-22, release date: 2022-07-27, Last modification date: 2023-10-18) |
Primary citation | Samuels, E.R.,Sevrioukova, I.F. Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imposed on the Heme-Ligating Group and the End-Pyridine Attachment. Int J Mol Sci, 23:-, 2022 Cited by PubMed: 35806297DOI: 10.3390/ijms23137291 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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