7UFE

Human CYP3A4 bound to an inhibitor

Summary for 7UFE

Entry DOI	10.2210/pdb7ufe/pdb
Descriptor	Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ... (5 entities in total)
Functional Keywords	cyp3a4, inhibitor, complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	113869.88
Authors	Sevrioukova, I.F. (deposition date: 2022-03-22, release date: 2022-07-27, Last modification date: 2023-10-18)
Primary citation	Samuels, E.R.,Sevrioukova, I.F. Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imposed on the Heme-Ligating Group and the End-Pyridine Attachment. Int J Mol Sci, 23:-, 2022 Cited by PubMed: 35806297 DOI: 10.3390/ijms23137291 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation