7UFB

CYP3A4 bound to an inhibitor

7UFB の概要

• エントリーDOI: 10.2210/pdb7ufb/pdb
• 分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, (2R)-3-phenyl-2-({(2S)-3-phenyl-2-[2-(pyridin-3-yl)acetamido]propyl}sulfanyl)-N-[(pyridin-3-yl)methyl]propanamide, ... (4 entities in total)
• 機能のキーワード: cyp3a4, inhibitor, complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56898.97

構造登録者

Sevrioukova, I. (登録日: 2022-03-22, 公開日: 2022-07-27, 最終更新日: 2023-10-18)

• 主引用文献: Samuels, E.R.,Sevrioukova, I.F.; Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imposed on the Heme-Ligating Group and the End-Pyridine Attachment.; Int J Mol Sci, 23:-, 2022; PubMed: 35806297; DOI: 10.3390/ijms23137291

実験手法

X-RAY DIFFRACTION (2.25 Å)