7UFA

CYP3A4 bound to an inhibitor

7UFA の概要

• エントリーDOI: 10.2210/pdb7ufa/pdb
• 分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-{[(2R)-1-oxo-3-phenyl-1-{[3-(pyridin-4-yl)propyl]amino}propan-2-yl]sulfanyl}-3-phenylpropan-2-yl]carbamate, ... (4 entities in total)
• 機能のキーワード: cyp3a4, inhibitor, complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56908.02

構造登録者

Sevrioukova, I. (登録日: 2022-03-22, 公開日: 2022-07-27, 最終更新日: 2023-10-18)

• 主引用文献: Samuels, E.R.,Sevrioukova, I.F.; Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imposed on the Heme-Ligating Group and the End-Pyridine Attachment.; Int J Mol Sci, 23:-, 2022; PubMed: 35806297; DOI: 10.3390/ijms23137291

実験手法

X-RAY DIFFRACTION (2.5 Å)