7UAM
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with (6-(3-(4,4-difluoropiperidin-1-yl)propyl)-4-methylpyridin-2-amine)
7UAM の概要
エントリーDOI | 10.2210/pdb7uam/pdb |
分子名称 | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
機能のキーワード | nitric oxide synthase inhibitor, heme enzyme, oxidoreductase |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 201178.77 |
構造登録者 | |
主引用文献 | Vasu, D.,Li, H.,Hardy, C.D.,Poulos, T.L.,Silverman, R.B. 2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors. Bioorg.Med.Chem., 69:116878-116878, 2022 Cited by PubMed: 35772285DOI: 10.1016/j.bmc.2022.116878 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.837 Å) |
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